Producto del catálogo Hycult Biotech. Referencia del fabricante: HM2393.
Monoclonal antibody clone Tx31 recognizes human Nectin-2. Nectin-2 was initially discovered as a poliovirus receptor-related protein (PRR2). Nectins are immunoglobulin-like transmembrane cell adhesion molecules expressed in various cell types. The nectin family consist of 4 members. Nectin-1/2/3 are expressed in cells like fibroblast, epithelial cells and neurons. Nectin-2 is also expressed in hematopoietic cells and spermatids. Nectins, which are ca2+-independent immunoglobulin like molecules, regulate cell-cell adhesions. They are involved in different type of disease like viral infection, autism, Alzheimer and cancer. Nectin-2 is believed to form homodimers or heterodimers in their function for cell adhesion. It forms an immune costimulatory function together with DNAM-1 thereby regulating both NK and CTL function.
- Reactividad / especie: Human
- Aplicaciones: Flow cytometry, Functional studies, Western blot
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