Producto del catálogo AbboMax. Referencia del fabricante: 500-12604.
"The 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14.3.3 zeta protein is a ubiquitous and abundant in brain. 14.3.3 zeta binds primarily to Raf noncatalytic sequences without inhibiting the Ras-Raf association or Raf-catalyzed MEK phosphorylation, thus it might act as a sweeper of misfolded protein by facilitating the formation of aggregates (inclusion bodies). Hence, 14-3-3 zeta may be considered as an auxiliary therapeutic tool in the protein aggregation disorders."
- Especificidad: "This antibody recognizes ~30 kDa of human 14.3.3 zeta protein. This antibody reacts with human, mouse and rat. The other species are not tested."
- Inmunógeno / antígeno: A synthetic peptide corresponding to the internal sequence (134-149aa) of human 14-3-3 zeta.
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