Producto del catálogo AbboMax. Referencia del fabricante: 600-080.
"Breast cancer anti-estrogen resistance 3 (BCAR3) is a also known as AND-34/BCAR3/NSP2 (BCAR3). Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. BCAR3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48"
- Especificidad: This antibody recognizes phosphorylated Threonin 130 of human BCAR3 protein. It does not recognize the nonphosphorylated BCAR3.
- Inmunógeno / antígeno: "A synthetic peptide surrounding of RHIMDR-T*-PEKLK of human BCAR3 protein with a single phosphorylation site at Thr 130. This sequence is identical to human, rat, mouse, canis and bovine."
Solicítenos una cotización indicando el código. Ficha técnica completa disponible en el fabricante.