Producto del catálogo AbboMax. Referencia del fabricante: 600-270.
"Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. It is a ubiquitous serine/threonine protein kinase which is abundant in brain as a major PSD constituent. This enzyme is composed of distinct but related subunits (alpha, beta, gamma, and delta) . The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP. The most important autophosphorylation site is Threonine 286, which resides in the vicinity of the autoinhibitory domain."
- Especificidad: This antibody recognizes CamKII(pT286) with a phosphorylated site of Threonine 286. It does not cross-react with non-phosphospecific peptide.
- Inmunógeno / antígeno: A synthetic peptide corresponding to the epitope with a single phosphorylation site Thr 286.
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