Producto del catálogo AbboMax. Referencia del fabricante: 601-610.
"Three homologues of CDC25 called CDC25A/B/C Cdc25 tyrosine phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes CDK1 (CDC2). Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by CDC25 phosphatases is a key step in the activation of the CDK1-cycline B protein kinase. Of the three mammalian Cdc25 isoforms, Cdc25A is phosphorylated by genotoxic stress-activated Chk1 or Chk2, which triggers its SCFbeta-TrCP-mediated degradation. CDC25B is degraded by the proteasome. CDK1-cyclin A phosphorylation targets CDC25B for degradation and this might be an important component of cell cycle regulation at the G2/M transition. "
- Especificidad: This antibody recognizes phosphorylated Serine 42 of human CDC25B protein. It does not recognize the nonphosphorylated CDC25B.
- Inmunógeno / antígeno: A synthetic peptide surrounding of –LGSPV- of human CDC25B protein with a phosphorylation site Serine 42.
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