Producto del catálogo Hycult Biotech. Referencia del fabricante: HK404.
Fatty acid-binding proteins (FABPs) are a class of cytoplasmic proteins that bind long chain fatty acids. FABPs are small intracellular proteins (~13-14 kDa) with a high degree of tissue specificity. They are abundantly present in various cell types and play an important role in the intracellular utilization of fatty acids, transport and metabolism. There are at least nine distinct types of FABP, each showing a specific pattern of tissue expression. Due to its small size, FABP leaks rapidly out of ischemically damaged necrotic cells leading to a rise in serum levels. Ischemically damaged tissues are characterized histologically by absence (or low presence) of FABP facilitating recognition of such areas. Liver-type fatty acid binding protein (L-FABP, FABP1) is predominantly expressed in liver. The L-FABP protein is derived from the human FABP1 gene. L-FABP is a sensitive marker for cell damage of liver cells in vitro and in vivo. L-FABP is also a marker for rapid hepatocyte lysis in vitro (as for example in toxicology assays) and for detection of liver damage during and after transplantation. Serum/plasma and urine of healthy individuals contains approximately 12 ng/ml and 16 ng/ml L-FABP, respectively.
- Reactividad / especie: Human
- Aplicaciones: The human L-FABP ELISA kit is to be used for the in vitro quantitative determination of human L-FABP in serum, plasma, urine, and cell culture supernatant samples. This kit can also be used for in vitro quantitative determination of swine L-FABP in serum, plasma, urine, and cell culture supernatant samples. In order to determine the results for swine, calculated concentrations should be multiplied with 1.8.
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