Producto del catálogo Hycult Biotech. Referencia del fabricante: HM1149.
Rat monoclonal antibody clone TX99 recognizes murine T cell immunoglobulin and ITEM domain (TIGIT). It is a inhibitory immune-checkpoint implicated in tumor immunosurveillance. The receptor is predominantly expressed on NK cells and several T-cells (effector, memory and regulatory).
TIGIT consists of a extracellular immunoglobulin variable domain, a type I inhibitory motif (ITIM) and a immunoglobulin tyrosine tail (ITT)-like motif. The homology between mouse and human is 58%, however the cytoplasmic tail between human and mice is identical. The main ligand of TIGIT is CD155 (PVR), which is highly expressed on APC’s, activated T-cells and some tumor cells. Another ligand is CD112 (nectin-2).
TIGIT negatively regulates antitumor responses, but promotes autoimmune reaction. When binding to CD155 it enhances the inhibitory function of Tregs by inducing IL-10. Binding to NK cells suppresses cytotoxicity and IFN-gamma expression. TIGIT is upregulated in a variety of different cancers. TIGIT has emerged as an attractive target for cancer therapy. Upregulation has also been found in SLE and rheumatoid arthritis. TIGIT has also been found to regulate antiviral responses like HIV infection. Antibody TX99 interferes with the interaction with CD155 and enhances NK-cell mediated cytotoxicity against CD155-expressing RMA-S-cells. The antibody has neutralizing capacity.
- Reactividad / especie: Mouse
- Aplicaciones: Frozen sections, Functional studies
Solicítenos una cotización indicando el código. Ficha técnica completa disponible en el fabricante.