Producto del catálogo Hycult Biotech. Referencia del fabricante: HC4074.
The TLR9 antagonist HC4074 targets mouse Toll-like receptor 9, inhibiting its activity to modulate immune responses. TLR9, distinctively located intracellularly, plays a pivotal role in recognizing pathogen DNA, differentiating between methylated vertebrate DNA and unmethylated pathogen DNA. This receptor’s activation within endosomal compartments triggers significant immune signaling pathways, engaging key proteins like MyD88. TLR9’s function in the immune system’s defense mechanism against various pathogens highlights its importance in research, particularly in conditions like arthritis and SLE, where specific synthetic ODNs like ODN2088 act as potent inhibitors.
- Reactividad / especie: Mouse
- Aplicaciones: Functional studies
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