Producto del catálogo Hycult Biotech. Referencia del fabricante: HM2213.
The monoclonal antibody 174-5 binds to Vascular Adhesion Protein-1 (VAP-1) , a glycosylated homodimeric membrane protein. It consists of two 90 kDa subunits linked by disulfide bonds. VAP-1 has a short N-terminal cytoplasmic tail, a transmembrane domain, and a large extracellular region . A soluble form, sVAP-1 , forms when proteolytic enzymes cleave membrane-bound VAP-1.
VAP-1 functions as a semicarbazide-sensitive amine oxidase (SSAO) with copper as a cofactor. It deaminates primary amines , producing hydrogen peroxide, aldehydes, and ammonia . These byproducts play key roles in inflammation, immune cell migration, and metabolism .
VAP-1 is found in endothelial cells, smooth muscle cells, adipocytes, and follicular dendritic cells . In endothelial cells, it remains stored in intracellular granules until inflammation triggers its surface expression. At the cell surface, VAP-1 regulates leukocyte infiltration into tissues . Its enzymatic byproducts signal immune cells, influence metabolism, and contribute to vascular damage .
High sVAP-1 levels are linked to inflammatory diseases, colorectal cancer, and metabolic disorders . Reduced insulin secretion increases sVAP-1 in plasma , suggesting its role as a biomarker and therapeutic target .
Monoclonal antibody 174-5 cross-reacts with rat VAP-1 and inhibits lymphocyte infiltration in rat liver allograft rejection models . Researchers use it to study VAP-1’s role in inflammation, immune regulation, and vascular disease .
- Reactividad / especie: Human
- Aplicaciones: Flow cytometry, Frozen sections, Functional studies, Immuno fluorescence
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